Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

摘要: Quantitative cardiac function assessment remains a challenge for physiologists and clinicians. Although historically invasive methods have comprised the only means available, development of noninvasive imaging modalities (echocardiography, MRI, CT) having high temporal spatial resolution provide new window quantitative diastolic assessment. Echocardiography is agreed upon standard assessment, but indexes in current clinical use merely utilize selected features chamber dimension (M-mode) or blood/tissue motion (Doppler) waveforms without incorporating physiologic causal determinants itself. The recognition that all left ventricles (LV) initiate filling by serving as mechanical suction pumps allows global to be assessed based on laws apply chambers. What differentiates one heart from another are parameters equation governs filling. Accordingly, Parametrized Diastolic Filling (PDF) formalism has shown entire range clinically observed early transmitral flow (Doppler E-wave) patterns extremely well fit damped oscillatory motion. This permits analysis individual E-waves accordance with mechanism (recoil-initiated suction) yields three (numerically) unique lumped whose analogues stiffness (k), viscoelasticity/relaxation (c), load (xo). The recording E-waves) practice cardiology and, therefore, echocardiographic method briefly reviewed. Our focus determination PDF routinely recorded E-wave data. As highlighted results indicate, once been obtained suitable number varying E-waves, investigator free construct (such stored energy 1/2kxo2, maximum A-V pressure gradient kxo, independent index function, etc.) select aspect physiology pathophysiology quantified.