The rs1447295 at 8q24 is a risk variant for prostate cancer in Taiwanese men.
作者： Marcelo Chen , Yu-Chuen Huang , I-ling Ko , Stone Yang , Yen-Hwa Chang
DOI: 10.1016/J.UROLOGY.2009.02.035
关键词: Genotype 、 Allele 、 Oncology 、 Cancer 、 Genotyping 、 Prostate cancer 、 Gynecology 、 Internal medicine 、 Odds ratio 、 Risk factor 、 Disease 、 Medicine
摘要: Objectives To determine the association of a common variant, rs1447295, at 8q24 region with prostate cancer (PCa) risk in Taiwanese men. Common variants have been shown to be associated PCa risk. The variant rs1447295 has strongest association. Most studies performed European and American populations. Methods This case-control study comprised 340 patients 337 controls. Genotyping was for rs14417295 test between its allele PCa. Its disease stage, Gleason score, PSA level, aggressiveness also determined. Results A significantly increased (odds ratio=1.49, 95% CI=1.12-1.99). When compared controls, more frequent both stages I+II ( P = .028) III+IV .023), all scores 20 ng/mL .001), aggressive .005). Conclusions confirmed that is high
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