Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men.
作者： Marcelo Chen , Yu-Chuen Huang , Stone Yang , Jong-Ming Hsu , Yen-Hwa Chang
DOI: 10.1002/PROS.21084
关键词: Risk factor 、 Prostate 、 Prostate cancer 、 Cancer 、 Carcinoma 、 Disease 、 Oncology 、 Internal medicine 、 Gynecology 、 Allele 、 Genotype 、 Medicine
摘要: BACKGROUND Recently, independent genome-wide scans have found multiple genetic variants at 8q24 to be associated with prostate cancer risk. This study was performed determine whether two of the more strongly risk in European and American populations, specifically rs16901979 rs6983561, were also Taiwanese men. METHODS We conducted a case–control comprising 340 patients 336 healthy controls. Genotyping for rs6983561. Their association disease stage, tumor grade, PSA level aggressiveness determined. RESULTS The allele A 1.28-fold increase (P = 0.046), C rs6983561 1.40-fold (P = 0.006). When compared controls, frequent aggressive disease. Analysis cumulative rs1447295, confirmed variant, one these markers showed that men who do not any variants, carry combination 1 or 2 genotypes gradually increased (P trend <0.001). CONCLUSION The are men. Prostate 70: 502–507, 2010. © 2009 Wiley-Liss, Inc.
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