Association of genetic and non-genetic risk factors with the development of prostate cancer in Malaysian men.

摘要: There is growing global interest to stratify men into different levels of risk developing prostate cancer, thus it important identify common genetic variants that confer the risk. Although many studies have identified more than a dozen which are highly associated with none been done in Malaysian population. To determine association such we evaluated panel 768 SNPs found previously various cancers also included specific population based case control study (51 subjects cancer and 51 subjects) Malay, Chinese Indian ethnicity. We 21 significantly cancer. Among these, 12 were strongly increased while remaining nine reduced However, data analysis on ethnic stratification led only five Malays 3 remained significant. This could be due small sample size each group. Significant non-genetic factors for their Our first investigate involvement multiple towards susceptibility PC using genotyping approach. Identified significant