Cumulative Association of Five Genetic Variants with Prostate Cancer
作者： S. Lilly Zheng , Jielin Sun , Fredrik Wiklund , Shelly Smith , Pär Stattin
DOI: 10.1056/NEJMOA075819
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摘要: Background Single-nucleotide polymorphisms (SNPs) in five chromosomal regions — three at 8q24 and one each 17q12 17q24.3 have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger. Methods We evaluated 16 from Swedish population (2893 subjects cancer 1781 control subjects) assessed individual combined of Results Multiple were single analysis. When most significant was selected included multivariate analysis, remained after adjustment for other family history. Together, history estimated to account 46% cases men we studied. The plus had cumulative w...
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L.E. Johns, R.S. Houlston, A systematic review and meta-analysis of familial prostate cancer risk BJU International. ,vol. 91, pp. 789- 794 ,(2003) , 10.1046/J.1464-410X.2003.04232.X
Sara Lindström, Fredrik Wiklund, Hans-Olov Adami, Katarina Augustsson Bälter, Jan Adolfsson, Henrik Grönberg, None, Germ-Line Genetic Variation in the Key Androgen-Regulating Genes Androgen Receptor, Cytochrome P450, and Steroid-5-α-Reductase Type 2 Is Important for Prostate Cancer Development Cancer Research. ,vol. 66, pp. 11077- 11083 ,(2006) , 10.1158/0008-5472.CAN-06-3024
M. L. Freedman, C. A. Haiman, N. Patterson, G. J. McDonald, A. Tandon, A. Waliszewska, K. Penney, R. G. Steen, K. Ardlie, E. M. John, I. Oakley-Girvan, A. S. Whittemore, K. A. Cooney, S. A. Ingles, D. Altshuler, B. E. Henderson, D. Reich, Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 14068- 14073 ,(2006) , 10.1073/PNAS.0605832103
David J. Hunter, Peter Kraft, Drinking from the Fire Hose — Statistical Issues in Genomewide Association Studies The New England Journal of Medicine. ,vol. 357, pp. 436- 439 ,(2007) , 10.1056/NEJMP078120
David E. Lilienfeld, Abraham M. Lilienfeld, Foundations of Epidemiology ,(1980)
Liang Wang, Shannon K. McDonnell, Joshua P. Slusser, Scott J. Hebbring, Julie M. Cunningham, Steven J. Jacobsen, James R. Cerhan, Michael L. Blute, Daniel J. Schaid, Stephen N. Thibodeau, Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. Cancer Research. ,vol. 67, pp. 2944- 2950 ,(2007) , 10.1158/0008-5472.CAN-06-3186
Christopher A Haiman, Nick Patterson, Matthew L Freedman, Simon R Myers, Malcolm C Pike, Alicja Waliszewska, Julie Neubauer, Arti Tandon, Christine Schirmer, Gavin J McDonald, Steven C Greenway, Daniel O Stram, Loic Le Marchand, Laurence N Kolonel, Melissa Frasco, David Wong, Loreall C Pooler, Kristin Ardlie, Ingrid Oakley-Girvan, Alice S Whittemore, Kathleen A Cooney, Esther M John, Sue A Ingles, David Altshuler, Brian E Henderson, David Reich, Multiple regions within 8q24 independently affect risk for prostate cancer. Nature Genetics. ,vol. 39, pp. 638- 644 ,(2007) , 10.1038/NG2015
Julius Gudmundsson, Patrick Sulem, Andrei Manolescu, Laufey T Amundadottir, Daniel Gudbjartsson, Agnar Helgason, Thorunn Rafnar, Jon T Bergthorsson, Bjarni A Agnarsson, Adam Baker, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Margret Jakobsdottir, Jianfeng Xu, Thorarinn Blondal, Jelena Kostic, Jielin Sun, Shyamali Ghosh, Simon N Stacey, Magali Mouy, Jona Saemundsdottir, Valgerdur M Backman, Kristleifur Kristjansson, Alejandro Tres, Alan W Partin, Marjo T Albers-Akkers, Javier Godino-Ivan Marcos, Patrick C Walsh, Dorine W Swinkels, Sebastian Navarrete, Sarah D Isaacs, Katja K Aben, Theresa Graif, John Cashy, Manuel Ruiz-Echarri, Kathleen E Wiley, Brian K Suarez, J Alfred Witjes, Mike Frigge, Carole Ober, Eirikur Jonsson, Gudmundur V Einarsson, Jose I Mayordomo, Lambertus A Kiemeney, William B Isaacs, William J Catalona, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson, Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nature Genetics. ,vol. 39, pp. 631- 637 ,(2007) , 10.1038/NG1999
Fredrick R. Schumacher, Heather Spencer Feigelson, David G. Cox, Christopher A. Haiman, Demetrius Albanes, Julie Buring, Eugenia E. Calle, Stephen J. Chanock, Graham A. Colditz, W. Ryan Diver, Alison M. Dunning, Matthew L. Freedman, John M. Gaziano, Edward Giovannucci, Sue E. Hankinson, Richard B. Hayes, Brian E. Henderson, Robert N. Hoover, Rudolf Kaaks, Timothy Key, Laurence N. Kolonel, Peter Kraft, Loic Le Marchand, Jing Ma, Malcolm C. Pike, Elio Riboli, Meir J. Stampfer, Daniel O. Stram, Gilles Thomas, Michael J. Thun, Ruth Travis, Jarmo Virtamo, Gerald Andriole, Edward Gelmann, Walter C. Willett, David J. Hunter, A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Research. ,vol. 67, pp. 2951- 2956 ,(2007) , 10.1158/0008-5472.CAN-06-3591
Gianluca Severi, Vanessa M. Hayes, Emma J.D. Padilla, Dallas R. English, Melissa C. Southey, Robert L. Sutherland, John L. Hopper, Graham G. Giles, The Common Variant rs1447295 on Chromosome 8q24 and Prostate Cancer Risk: Results from an Australian Population-Based Case-Control Study Cancer Epidemiology, Biomarkers & Prevention. ,vol. 16, pp. 610- 612 ,(2007) , 10.1158/1055-9965.EPI-06-0872