A common 8q24 variant in prostate and breast cancer from a large nested case-control study.

摘要: Two recent studies independently identified polymorphisms in the 8q24 region, including a single nucleotide polymorphism (rs1447295), strongly associated with prostate cancer risk. Here, we replicate overall association large nested case-control study from National Cancer Institute Breast and Prostate Cohort Consortium using 6,637 cases 7,361 matched controls. We also examine whether this is breast among 2,604 Caucasian 3,118 The rs1447295 marker was Caucasians (P = 1.23 × 10−13). When exclude Multiethnic samples, previously reported by Freedman et al., remains highly significant 8.64 Compared wild-type homozygotes, carriers one copy of minor allele had an ORAC 1.34 (99% confidence intervals, 1.19–1.50) two copies ORAA 1.86 1.30–2.67). Among African Americans, genotype statistically men diagnosed at early age 0.011) nonsignificant for those later 0.924). This difference risk diagnosis not present Caucasians. found no when tumors were classified Gleason score, stage, or mortality. between 0.590). Although gene responsible has yet to be identified, validation sample leaves little room possibility false-positive result. [Cancer Res 2007;67(7):2951–6]