Suicidality and 5-Hydroxyindoleacetic Acid Concentration Associated With a Tryptophan Hydroxylase Polymorphism
作者： David A Nielsen , David Goldman , Matti Virkkunen , Riitta Tokola , Robert Rawlings
DOI: 10.1001/ARCHPSYC.1994.03950010034005
关键词: Serotonin 、 Endocrinology 、 Genotype 、 Cerebrospinal fluid 、 Tryptophan hydroxylase 、 Impulsivity 、 Enzyme 、 5-Hydroxyindoleacetic acid 、 Internal medicine 、 Psychology 、 Poison control 、 Psychiatry
摘要: Background: To examine whether the tryptophan hydroxylase (TPH) gene, which codes for rate-limiting enzyme in biosynthesis of serotonin, may be a factor influencing serotonin turnover and behaviors controlled by serotonin. Methods: Using polymerase chain reaction—based method, TPH genotype was determined DNA samples from 56 impulsive 14 nonimpulsive, alcoholic, violent offenders 20 healthy volunteers. Results: In behaviorally extreme group, we observed significant association between cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) concentration. No with behavior detected. The polymorphism also associated history suicide attempts all offenders, independent impulsivity status 5-HIAA Conclusion: some individuals, genetic variant gene influence concentration predisposition to suicidal behavior.
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