Ultrasound Microbubble-Mediated microRNA-505 Regulates Cervical Cancer Cell Growth via AKT2.
作者： Leilei Xu , Qin Zhang , Changhua Li , Fu Hua , Xiaoping Liu
DOI: 10.1155/2020/3731953
关键词: Apoptosis 、 HeLa 、 Cell growth 、 Cell cycle 、 Chemistry 、 microRNA 、 Cancer research 、 Transfection 、 Cell 、 Gene delivery
摘要: The application of ultrasound and microbubbles (USMB-) mediated microRNA (miR) is a promising approach gene delivery for cancer treatment. We aimed to discuss the effects USMB-miR-505 on cervical (CC) development. miR-505 by USMB was prepared. effect its transfection efficiency HeLa cell proliferation, cycle, apoptosis, migration, invasion were studied. target predicted, expression in CC detected. cells further verified. showed higher than alone. inhibitory better miR-505. targeted AKT2, which upregulated CC. Overexpression AKT2 reversed malignant behaviors. Overall, we highlighted that inhibited behaviors targeting AKT2.
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