Decoding the molecular mechanisms of neuronal migration using in utero electroporation
作者： Hidenori Tabata , Koh-ichi Nagata
DOI: 10.1007/S00795-015-0127-Y
关键词: Cell 、 In utero 、 Biology 、 Subventricular zone 、 Cerebral cortex 、 Electroporation 、 Cell biology 、 Bioinformatics 、 Gene knockdown 、 Phenotype 、 Molecular medicine
摘要: During the development of cerebral cortex, excitatory neurons are produced in ventricular zone lining lateral ventricle or adjacent subventricular and migrate toward brain surface a process known as radial migration. migration, undergo multiple steps including multipolar cell phase, multipolar-bipolar transition, locomotion phase. Many genes tightly regulate behavior each We have established an utero electroporation method rapid vivo gene transfer system, this system has greatly contributed to recent advances our knowledge molecular mechanisms underlying migration Here, we review behaviors during phase involved these phases. Knockdown functional blocking using results various defects abnormal morphologies. describe phenotypes much possible so that can be used chart evaluate novel knockdown experiments. also discuss application studies examining functions neurodevelopmental disorder-related genes.
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