作者: Adriano Nunes Kochi et al
DOI: 10.22541/AU.158594433.36475644
关键词: Respiratory system 、 Pandemic 、 Drug toxicity 、 QT interval 、 Cardiology 、 Hypoxia (medical) 、 Internal medicine 、 Etiology 、 Medicine 、 Adrenergic 、 Coronavirus disease 2019 (COVID-19)
摘要: In December 2019, the world started to face a new pandemic situation, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 clinical manifestations are mainly respiratory, major cardiac complications being reported. Cardiac etiology seems be multifactorial, comprising direct viral myocardial damage, hypoxia, hypotension, enhanced inflammatory status, ACE2-receptors downregulation, drug toxicity, endogenous catecholamine adrenergic among others. Studies evaluating patients presenting injury markers show that it is associated with poorer outcomes, and arrhythmic events not uncommon. Besides, drugs currently used treat known prolong QT interval can have proarrhythmic propensity. This review focus on and, in parallel, makes an appraisal of other virus epidemics as SARS-CoV, MERS-CoV, H1N1 influenza.