Aggressive serous epithelial ovarian cancer is potentially propagated by EpCAM+CD45+ phenotype.

摘要: Epithelial ovarian carcinoma (EOC) patients often acquire resistance against common chemotherapeutic drugs like paclitaxel and cisplatin. The mechanism responsible for the same is ambiguous. We have identified a putative drug-resistant tumour cell phenotype (EpCAM+CD45+) in ascitic fluid of EOC patients, which appears to originate from primary tumour. These cells represent major burden are more drug resistant compared EpCAM+ due over-expression SIRT1, ABCA1 BCL2 genes. found that entire EpCAM+CD45+ population highly invasive with signature mesenchymal gene expression also consists subpopulations cancer stem (CD133+ CD117+CD44+). Additionally, we demonstrate over-express histocompatibility complex class I antigen, enable them evade natural killer cell-mediated immune surveillance. Preliminary evidence obtained OVCAR-5 suggests exosomes, secreted by non-tumour fluid, play an important role rendering properties cells. Identification such aggressive deciphering their origin designing better targets EOC.