Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults

摘要: Background Two individuals can have a similar pulse pressure (PP) but different levels of systolic blood (SBP), although the underlying mechanisms not been described. We hypothesized that, for given level PP, differences in SBP relate to peripheral vascular resistance (PVR); and we tested this hypothesis large cohort healthy young adults. Methods Results Demographic, biochemical, hemodynamic data from 3103 subjects were available current analyses. In both men women, higher was associated with significantly body weight, mass index, heart rate, PVR (P<0.05 versus those lower BP all comparisons). Moreover, stratifying by quartiles PP revealed stepwise increase lowest highest quartile each variable, occurring (P<0.001 overall trend sexes). also increased increasing tertile minimum forearm resistance, (P=0.002) women (P=0.03). Conclusions Increased PVR, mediated part through altered vessel structure, strongly associates elevation An impaired ability adapt appropriately may be an important mechanism elevated