Gut Microbiota-Mediated Transformation of Coptisine Into a Novel Metabolite 8-Oxocoptisine: Insight Into Its Superior Anti-Colitis Effect.
作者： Jianhui Xie , Jiannan Chen , Yucui Li , Ziren Su , Yuhong Liu
DOI: 10.3389/FPHAR.2021.639020
关键词: Metabolite 、 Gut flora 、 Pharmacology 、 Ulcerative colitis 、 Cytokine 、 Coptisine 、 NF-κB 、 Inflammasome 、 Chemistry 、 Colitis
摘要: Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Coptis Chinemsis Franch, which is traditionally applied for the management of colitis. However, the blood …
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