Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy

摘要: Aims To investigate the prognostic impact of left-ventricular (LV) cardiac magnetic resonance (CMR) deformation imaging in patients with non-ischaemic dilated cardiomyopathy (DCM) compared late-gadolinium enhancement (LGE) quantification and LV ejection fraction (EF). Methods results A total 210 subjects DCM were examined prospectively standard CMR including measurement LGE for myocardial fibrosis feature tracking strain assessment deformation. The predefined primary endpoint, a combination death, heart transplantation, aborted sudden occurred 26 during median follow-up period 5.3 years. radial, circumferential, longitudinal strains significantly associated outcome. Using separate multivariate analysis models, global (average peak negative values) mean (negative curve all segments) independent parameters surpassing value radial circumferential strain, as well NT-proBNP, EF, mass. greater than −12.5% predicted outcome even EF < 35% ( P 0.01) those presence 0.001). Mean was further investigated using clinical model cut-offs (EF 35%, LGE, NYHA class, −10%). exhibited an that provided by NYHA, (HR = 5.4, 0.01). Conclusion assessed is predictor survival offers incremental information risk stratification beyond parameters, biomarker, CMR.