Short-term in vitro and in vivo bioassays: their role in estimating the toxic potential of inhaled complex mixtures for humans.

摘要: Experimental pathology and toxicology has frequently advanced because of the addition newdiagnostic tools. During last decade, bronchoalveolar lavage emerged as a very usefultool in assessment lung injury. It is applicable to both animal models exposed toinhaled particles gases laboratory humans encountering exposures sameagents occupational urban environments. Information can be gathered from BALrelating extent type injury mechanisms involved. Needed are moreextensive comparisons judged by other approaches with results BAL. Forexample, short-term bioassay integrated industrial hygiene andepidemiology was done recent study talc granite dusts (Beck, 1987). isalso likely that constituents BAL quantified which will help make bioassaysutilizing more specific sensitive. The use assays bean important source information regarding toxicity new poorly characterizedinhaled particles.The cells contained worthy further since macrophages otherphagocytic occupy central role pathogenesis These preventinfection, involved particle clearance, but also contribute disease when activatedand/or damaged. Continuing development methods inevitably lead additionalinsights into how environmental