New approaches for the evaluation of pulmonary toxicity: bronchoalveolar lavage fluid analysis.
作者： R HENDERSON
DOI: 10.1016/0272-0590(85)90092-2
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摘要: Analysis of bronchoalveolar lavage fluid (BAL) is an effective method detecting inflammatory response in the lungs animals toxicological studies. Alterations BAL that are most sensitive indications increased content serum proteins and influx neutrophils (PMNs). Elevation cytoplasmic enzyme lactate dehydrogenase (LDH) a useful indicator cytotoxicity. The pulmonary to particles (either mineral dusts or soot) lung includes greatly activities such lysosomal enzymes as beta-glucuronidase beta-N-acetylglucosaminidase BAL. Examination alterations rats mice during chronic exposure high levels diluted diesel exhaust revealed steadily increasing LDH, beta-glucuronidase, hydroxyproline correlated better with development fibrosis than did measures (protein, PMNs). has proven useful, both for detection injury screening tests determination mechanisms developing disease. Future work shows promise assays analysis identify specific site type present.
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V J Ferrans, R G Crystal, O Kawanami, G W Hunninghake, J E Gadek, Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. American Journal of Pathology. ,vol. 97, pp. 149- 206 ,(1979)
A. H. Rebar, D. B. Denicola, B. A. Muggenburg, Bronchopulmonary lavage cytology in the dog: normal findings. Veterinary Pathology. ,vol. 17, pp. 294- 304 ,(1980) , 10.1177/030098588001700303
Dennis B. DeNicola, Alan H. Rebar, Rogene F. Henderson, Early damage indicators in the lung Toxicology and Applied Pharmacology. ,vol. 60, pp. 301- 312 ,(1981) , 10.1016/0041-008X(91)90233-5
P M Henson, B J Bentwood, The sequential release of granule constitutents from human neutrophils. Journal of Immunology. ,vol. 124, pp. 855- 862 ,(1980)
Eva Soto Leake, Quentin N. Myrvik, Bruce Fariss, Studies on Pulmonary Alveolar Macrophages from the Normal Rabbit: A Technique to Procure Them in a High State of Purity Journal of Immunology. ,vol. 86, pp. 128- 132 ,(1961)
S.R. Moores, A. Black, J.C. Evans, N. Evans, A. Holmes, A. Morgan, The effect of quartz, administered by intratracheal instillation, on the rat lung: II. The short-term biochemical response Environmental Research. ,vol. 24, pp. 275- 285 ,(1981) , 10.1016/0013-9351(81)90157-2
Roger Spragg, James Marsh, Jeffrey Schwartz, William Loomis, Bruce Krieger, Nonspecificity of elevated angiotensin-converting enzyme activity in bronchoalveolar lavage fluid from high permeability lung edema states. The American review of respiratory disease. ,vol. 129, pp. 499- 500 ,(1984) , 10.1164/ARRD.1984.129.3.499
Thomas R. Martin, Emil Y. Chi, David S. Covert, W. Alan Hodson, Dale E. Kessler, William E. Moore, Leonard C. Altman, John Butler, Comparative effects of inhaled volcanic ash and quartz in rats. The American review of respiratory disease. ,vol. 128, pp. 144- 152 ,(1983) , 10.1164/ARRD.1983.128.1.144
Repine Je, Fox Rb, Tate Rm, Harada Rm, Shasby Dm, Shasby Ss, Bowman Cm, Angiotensin converting enzyme concentrations in the lung lavage of normal rabbits and rabbits treated with nitrogen mustard exposed to hyperoxia. The American review of respiratory disease. ,vol. 124, pp. 202- ,(1981) , 10.1164/ARRD.1981.124.2.202
R.F. Henderson, A.H. Rebar, J.A. Pickrell, G.J. Newton, Early damage indicators in the lung. III. Biochemical and cytological response of the lung to inhaled metal salts Toxicology and Applied Pharmacology. ,vol. 50, pp. 123- 136 ,(1979) , 10.1016/0041-008X(79)90500-3