Effects of antiepileptic drugs on thalamocortical excitability.

摘要: Comparative effects of anticonvulsant drugs on the thalamocortical system were analyzed quantitatively. Paired stimuli delivered to ventrolateral thalamus with evoked responses recorded from ipsilateral sensorimotor cortex in cat. Threshold and excitability profiles developed an on-line computer. Effects phenytoin diazepam generally similar, depression slight elevation thresholds. Ethosuximide produced a pronounced pair-interval dependent effect unchanged or increased lowered threshold at shorter intervals, depressed raised longer intervals. These data demonstrate marked difference petit mal grand agents tested suggest basis for effectiveness ethosuximide controlling 3-per-second repetitive activity.