Wrapping/unwrapping transition of double-stranded DNA in DNA-nanosphere complexes induced by multivalent anions.
作者： Aihua Chai , Yangwei Jiang , Yaoyang Zhang , Linli He , Dong Zhang
DOI: 10.1039/C4SM00652F
关键词: Divalent 、 Ion 、 DNA 、 Chemistry 、 Double stranded 、 Electrostatic attraction 、 Molecular dynamics 、 Crystallography
摘要: Wrapping and unwrapping behaviors of double-stranded DNA around a positively charged nanosphere in solution are studied by using the coarse-grained molecular dynamics (CGMD) simulation method. When monovalent, divalent trivalent anions added to DNA–nanosphere complex solution, binds with owing strong electrostatic attraction. However, when tetravalent local charge inversion is observed for high anion concentration can be unwrapped from because near nanosphere. Moreover, helical structure damaged wraps rebuilt unwraps This study help us understand how control release complexes.
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