Decondensation behavior of DNA chains induced by multivalent cations at high salt concentrations: Molecular dynamics simulations and experiments*
作者： Yang-Wei Jiang , Shi-Yong Ran , Lin-Li He , Xiang-Hong Wang , Lin-Xi Zhang
DOI: 10.1088/1674-1056/24/11/118701
关键词:
摘要: Using molecular dynamics simulations and atomic force microscopy (AFM), we study the decondensation process of DNA chains induced by multivalent cations at high salt concentrations in presence short cationic solutions. The typical simulation conformations with varying for imply that concentration valence have a strong influence on decondensation. are condensed absence or low concentrations, compacted become loose when number anions added into solution. It is explicitly demonstrated can overcompensate bare charge weaken attraction interactions between concentrations. condensation-decondensation transitions also experimentally observed mixing spermidine λ-phage different NaCl/MgCl2
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