Antenatal taurine supplementation for improving brain ultrastructure in fetal rats with intrauterine growth restriction.

摘要: Changes in brain ultrastructure of fetal rats with intrauterine growth restriction (IUGR) were explored and the effects antenatal taurine supplementation on their determined. Fifteen pregnant randomly divided into three groups: control group, IUGR model group given supplements. Taurine was added to diet at a dose 300 mg/kg/d from 12 days after conception until natural delivery. Transmission electron microscopy used observe ultrastructural changes brains newborn rats. At same time, cellular apoptosis detected using TUNEL, protein expression neuron specific enolase glial fibrillary acidic analyzed immunohistochemistry. The results showed that: 1) average body weight cerebral significantly lower than (p<0.01) both them less so supplemented (p<0.01). 2) revealed that cortex structures sparse rats, showing many scattered apoptotic cells, decreased numbers synapses, cell proliferation, fewer neurons, more sparsely arranged, while these factors improved supplementation. 3) TUNEL counts cells groups increased those could decrease (p<0.001). 4) immunohistochemistry taurine-supplementation increase immunoreactive It can be concluded it has significant detrimental influence development rat brains, supplement improve development.