Extrafacial indolent CD8-positive cutaneous lymphoid proliferation with unusual symmetrical presentation involving both feet.

作者: Marion Wobser , Tony Petrella , Hermann Kneitz , Andreas Kerstan , Matthias Goebeler

DOI: 10.1111/CUP.12213

关键词: Cutaneous T-cell lymphomaDermatologyCD8PathologyBiologyPresentation (obstetrics)World healthProliferation indexDermatopathologyCancerLymphoma

摘要: Indolent CD8+ cutaneous lymphoid proliferation represents a recently described entity among T-cell lymphomas that typically presents with solitary skin lesions on the face or at acral sites and usually follows an indolent clinical course. Histopathologically, this is characterized by dense dermal infiltrate of non-epidermotropic, small- to medium-sized pleomorphic T-cells non-activated cytotoxic phenotype showing clear-cut grenz zone low index. Distinction from otherwise aggressive bearing fundamental. We herein present unusual case presenting in bilateral symmetrical distribution both feet lacking zone. Our widens spectrum possible histomorphological variations entity. Taking into account distinctive unique microscopic features all hitherto published cases we suppose lymphoma subtype has be included as new distinct World Health Organisation (WHO)-/European for Research Treatment Cancer (EORTC)-classification lymphomas.

参考文章(38)
L Azzoni, B Perussia, S F Wolf, T W Salcedo, Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. Journal of Immunology. ,vol. 151, pp. 2511- 2520 ,(1993)
Tony Petrella, Alistair Robson, Danielle Greenblatt, Mina Ally, Fiona Child, Julia Scarisbrick, Sean Whittaker, Stephen Morris, Eduardo Calonje, Indolent CD8+lymphoid proliferation of acral sites: a clinicopathologic study of six patients with some atypical features Journal of Cutaneous Pathology. ,vol. 40, pp. 248- 258 ,(2013) , 10.1111/CUP.12045
A. J. A. Ryan, A. Robson, B. D. Hayes, K. Sheahan, P. Collins, Primary cutaneous peripheral T-cell lymphoma, unspecified with an indolent clinical course: a distinct peripheral T-cell lymphoma? Clinical and Experimental Dermatology. ,vol. 35, pp. 892- 896 ,(2010) , 10.1111/J.1365-2230.2010.03849.X
Emilio Berti, Dario Tomasini, Maarten H Vermeer, Chris JLM Meijer, Elvio Alessi, Rein Willemze, Primary Cutaneous CD8-Positive Epidermotropic Cytotoxic T Cell Lymphomas : A Distinct Clinicopathological Entity with an Aggressive Clinical Behavior American Journal of Pathology. ,vol. 155, pp. 483- 492 ,(1999) , 10.1016/S0002-9440(10)65144-9
Ahmad Nofal, M. Yousry Abdel-Mawla, Magda Assaf, Eman Salah, Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma: Proposed diagnostic criteria and therapeutic evaluation Journal of The American Academy of Dermatology. ,vol. 67, pp. 748- 759 ,(2012) , 10.1016/J.JAAD.2011.07.043
A. Valois, C. Bastien, F. Granel-Broca, J.-F. Cuny, A. Barbaud, J.-L. Schmutz, Lymphome indolent de l’oreille Annales De Dermatologie Et De Venereologie. ,vol. 139, pp. 818- 823 ,(2012) , 10.1016/J.ANNDER.2012.10.578
Dorothee Eich, Hans Theodor Eich, Hans-Günter Otte, Voica Ghilescu, Rudolf Stadler, Photodynamische Therapie kutaner T-Zell-Lymphome in besonderer Lokalisation Hautarzt. ,vol. 50, pp. 109- 114 ,(1999) , 10.1007/S001050050873
Socorro Maria Rodríguez Pinilla, Giovanna Roncador, Jose Luis Rodríguez-Peralto, Manuela Mollejo, Juan Fernando García, Santiago Montes-Moreno, Francisca Inmaculada Camacho, Pablo Ortiz, Miguel Angel Limeres-González, Angeles Torres, Elías Campo, Pedro Navarro-Conde, Miguel Angel Piris, Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers. The American Journal of Surgical Pathology. ,vol. 33, pp. 81- 90 ,(2009) , 10.1097/PAS.0B013E31818E52FE
Z Fika, P D Karkos, K Badran, R E Williams, Primary cutaneous aggressive epidermotropic CD8 positive cytotoxic T-cell lymphoma of the ear. Journal of Laryngology and Otology. ,vol. 121, pp. 503- 505 ,(2007) , 10.1017/S0022215106005457