CD68 expression is a discriminative feature of indolent cutaneous CD8-positive lymphoid proliferation and distinguishes this lymphoma subtype from other CD8-positive cutaneous lymphomas.

摘要: SummaryBackground Indolent cutaneous CD8+ lymphoid proliferation is a recently described rare entity among T-cell lymphomas that typically presents with solitary skin lesions at acral sites. Separation from otherwise aggressive bearing cytotoxic phenotype fundamental to avoid unnecessary harmful treatment. However, up now, no reliable discriminative marker has been identified. Objectives Motivated by these diagnostic quandaries, we have analyzed large series of archived formalin-fixed paraffin-embedded (FFPE) specimens atypical infiltrates clear-cut diagnosis and clinical follow-up (n = 44) including five cases indolent using immunohistochemistry the aim obtaining markers predictive subtype assignment. Results We identified exclusive expression CD68 lymphoma cells within subgroup (5/5 cases). Specific in this was confirmed application several monoclonal antibodies (KP1, PG-M1, KiM1P) against molecule available for FFPE tissue. In contrast, none other entities stained positive (0/39). Conclusions Based on observations, suggest as new which helpful distinguishing ambiguous cases.