The role of fucosylation in the promotion of endothelial progenitor cells in neovascularization and bone repair
作者： Shengxuan Sun , Zhenzhen Liu , Haibin Zhou , Guoqiang Li , Meng Liu
DOI: 10.1016/J.BIOMATERIALS.2014.01.025
关键词: Neovascularization 、 Immunology 、 Progenitor cell 、 Homing (hematopoietic) 、 Cancer research 、 Sialyl-Lewis X 、 Umbilical vein 、 Tumor necrosis factor alpha 、 Selectin 、 Medicine 、 Angiogenesis
摘要: Abstract Bone marrow-derived endothelial progenitor cells (EPCs) are being tested as a therapy to treat variety of ischemic diseases. Poor homing targeted tissues is one the major factors limiting therapeutic efficacy EPCs. Here, we show that human cord blood-derived EPCs expressed little sialyl Lewis X (sLex) antigen necessary for selectin-mediated cell–cell interactions. Expression α1,3-fucosyltransferase VI (FucT VI) in enhanced sLex synthesis, E- and P-selectin-binding, EPC adhesion tumor necrosis factor-α-stimulated umbilical vein culture. In mouse model hind limb ischemia, which were injected intravenously, FucT expression increased homing, neovascularization, blood flow muscles. another femoral fracture, VI-expressing more efficient than control targeting peri-fracture enhance angiogenesis, bone repair. These results indicate fucosylated may be used an improved cellular source
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