A direct synthesis of a bifunctional chelating agent for radiolabeling proteins
作者： Martin W. Brechbiel , Thomas J. McMurry , Otto A. Gansow
DOI: 10.1016/S0040-4039(00)79202-1
关键词: Ion chromatography 、 Nitro compound 、 Chemistry 、 Yield (chemistry) 、 Organic chemistry 、 Alkylation 、 Ligand 、 Chelation 、 Bifunctional 、 Derivative (chemistry)
摘要: Abstract A convenient synthesis of a bifunctional derivative the ligand NOTA is described. The offers advantages over current literature methods for making similar molecules by starting with easily prepared ortho-amide 1,4,7-triazacyclanonane which can be sequentially alkylated to provide in 9% yield overall. replacement preparative HPLC simple ion-exchange chromatography provides analytically pure suitable clinical applications.
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