Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection

作者: Anne W Rimoin , Kai Lu , Matthew S Bramble , Imke Steffen , Reena H Doshi

DOI: 10.1093/INFDIS/JIX584

关键词: Plaque reduction neutralization testEbola virusAntibodyVirusOutbreakVirologyVP40MedicineSerologyNeutralization

摘要: … Some survivors from the original EBOV outbreak still harbor antibodies against all 3 measures. Interestingly, a subset of these survivors’ serum antibodies could still neutralize live virus …

参考文章(28)
Gary J. Nabel, Zhi-yong Yang, Henricus J. Duckers, Nancy J. Sullivan, Anthony Sanchez, Elizabeth G. Nabel, Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury Nature Medicine. ,vol. 6, pp. 886- 889 ,(2000) , 10.1038/78645
Yanchen Zhou, Imke Steffen, Leilani Montalvo, Tzong-Hae Lee, Reeve Zemel, William M. Switzer, Shaohua Tang, Hongwei Jia, Walid Heneine, Valerie Winkelman, Chetankumar S. Tailor, Yasuhiro Ikeda, Graham Simmons, Development and application of a high-throughput microneutralization assay: lack of xenotropic murine leukemia virus-related virus and/or murine leukemia virus detection in blood donors Transfusion. ,vol. 52, pp. 332- 342 ,(2012) , 10.1111/J.1537-2995.2011.03519.X
J.J. Muyembe-Tamfum, S. Mulangu, Justin Masumu, J.M. Kayembe, A. Kemp, Janusz T. Paweska, Ebola virus outbreaks in Africa: Past and present Onderstepoort Journal of Veterinary Research. ,vol. 79, pp. 451- 451 ,(2012) , 10.4102/OJVR.V79I2.451
Sinroku Otatume, Ebola haemorrhagic fever in Zaire Journal of African Studies. ,vol. 1996, pp. 95- 97 ,(1996) , 10.11619/AFRICA1964.1996.49_95
E. M. Leroy, S. Baize, P. Debre, J. Lansoud-Soukate, E. Mavoungou, Early immune responses accompanying human asymptomatic Ebola infections Clinical and Experimental Immunology. ,vol. 124, pp. 453- 460 ,(2001) , 10.1046/J.1365-2249.2001.01517.X
G. Simmons, D. N. Gosalia, A. J. Rennekamp, J. D. Reeves, S. L. Diamond, P. Bates, Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 11876- 11881 ,(2005) , 10.1073/PNAS.0505577102
Pierre Becquart, Nadia Wauquier, Tanel Mahlakõiv, Dieudonné Nkoghe, Cindy Padilla, Marc Souris, Benjamin Ollomo, Jean-Paul Gonzalez, Xavier De Lamballerie, Mirdad Kazanji, Eric M. Leroy, High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon PLoS ONE. ,vol. 5, pp. e9126- ,(2010) , 10.1371/JOURNAL.PONE.0009126
G. Simmons, J. D. Reeves, A. J. Rennekamp, S. M. Amberg, A. J. Piefer, P. Bates, Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 4240- 4245 ,(2004) , 10.1073/PNAS.0306446101
Graham Simmons, Rouven J. Wool-Lewis, Frédéric Baribaud, Robert C. Netter, Paul Bates, Ebola Virus Glycoproteins Induce Global Surface Protein Down-Modulation and Loss of Cell Adherence Journal of Virology. ,vol. 76, pp. 2518- 2528 ,(2002) , 10.1128/JVI.76.5.2518-2528.2002