Fasting biases brain reward systems towards high-calorie foods.

摘要: Nutritional state (e.g. fasted vs. fed) and different food stimuli high-calorie low-calorie, or appetizing bland foods) are both recognized to change activity in brain reward systems. Using functional magnetic resonance imaging, we have studied the interaction between nutritional on We examined how blood oxygen level-dependent within a priori regions of interest varied while viewing pictures low-calorie foods. Pictures non-food household objects were included as control stimuli. During scanning, subjects rated appeal each picture. Twenty non-obese healthy adults [body mass index 22.1 +/- 0.5 kg/m(2) (mean SEM), age range 19-35 years, 10 male] scanned two separate mornings 11:00 12:00 h, once after eating filling breakfast ('fed': 1.6 0.1 h since breakfast), an overnight fast but skipping ('fasted': 15.9 0.3 supper) randomized cross-over design. Fasting selectively increased activation over foods ventral striatum, amygdala, anterior insula, medial lateral orbitofrontal cortex (OFC). Furthermore, fasting enhanced subjective more than foods, bias towards was positively correlated with OFC activation. These results demonstrate homeostatic hedonic aspects feeding behaviour, biasing systems