Neuroimaging and Obesity

摘要: The hypothalamus has a major role in the control of food intake. However, neurotracing studies have shown that receives input from several other regions brain are likely to modulate its activity. Of particular interest understanding human eating behavior is possible involvement cortex. Using positron emission tomography (PET), we generated functional maps neuroanatomical correlates hunger (after 36-h fast) and satiation oral administration liquid formula meal) lean obese subjects. Results individuals indicate form complex network including hypothalamus, thalamus, limbic/paralimbic areas such as insula, hippocampal/parahippocampal formation, orbitofrontal Satiation was associated with preferentially increased neuronal activity prefrontal Our also responses hunger/satiation (commonly regulation emotion), cortex (thought be involved inhibition inappropriate response tendencies) might different individuals. In conclusion, neuroimaging proving an important tool for complexity behavior. PET help unravel neuropathophysiology underlying obesity.