Efficacy of the porcine species in biomedical research.
作者： Karina Gutierrez , Naomi Dicks , Werner G Glanzner , Luis B Agellon , Vilceu Bordignon
关键词: Somatic cell 、 Large animal 、 Computational biology 、 Domestication 、 Chronic disorders 、 Stem cell culture 、 Porcine species 、 Bioinformatics 、 Genome editing 、 Biology
摘要: Since domestication, pigs have been used extensively in agriculture and kept as companion animals. More recently they biomedical research, given share many physiological anatomical similarities with humans. Recent technological advances assisted reproduction, somatic cell cloning, stem culture, genome editing, transgenesis now enable the creation of unique porcine models human diseases. Here, we highlight potential applications advantages using pigs, particularly minipigs, indispensable large animal fundamental clinical including development therapeutics for inherited chronic disorders, cancers.
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Lawrence B. Schook, Tiago V. Collares, Kwame A. Darfour-Oduro, Arun Kumar De, Laurie A. Rund, Kyle M. Schachtschneider, Fabiana K. Seixas, Unraveling the swine genome: implications for human health. Annual Review of Animal Biosciences. ,vol. 3, pp. 219- 244 ,(2015) , 10.1146/ANNUREV-ANIMAL-022114-110815
Randall S. Prather, Monique Lorson, Jason W. Ross, Jeffrey J. Whyte, Eric Walters, Genetically Engineered Pig Models for Human Diseases Annual Review of Animal Biosciences. ,vol. 1, pp. 203- 219 ,(2013) , 10.1146/ANNUREV-ANIMAL-031412-103715
Shuji Miyagawa, Hiroshi Murakami, Yoichi Takahagi, Rie Nakai, Mako Yamada, Ayako Murase, Souichi Koyota, Masaru Koma, Katsuyoshi Matsunami, Daisuke Fukuta, Tatsuya Fujimura, Tamotsu Shigehisa, Masaru Okabe, Hiroshi Nagashima, Ryota Shirakura, Naoyuki Taniguchi, Remodeling of the Major Pig Xenoantigen by N-Acetylglucosaminyltransferase III in Transgenic Pig Journal of Biological Chemistry. ,vol. 276, pp. 39310- 39319 ,(2001) , 10.1074/JBC.M104359200
R. W. Phillips, L. M. Panepinto, R. Spangler, N. Westmoreland, Yucatan Miniature Swine as a Model for the Study of Human Diabetes Mellitus Diabetes. ,vol. 31, pp. 30- 36 ,(1982) , 10.2337/DIAB.31.1.S30
Shelley J. Newman, Barton Rohrbach, Pot-bellied pig neoplasia A retrospective case series (2004–2011) Journal of Veterinary Diagnostic Investigation. ,vol. 24, pp. 1008- 1013 ,(2012) , 10.1177/1040638712452725
Mirte Bosse, Ole Madsen, Hendrik-Jan Megens, Laurent A. F. Frantz, Yogesh Paudel, Richard P. M. A. Crooijmans, Martien A. M. Groenen, Hybrid origin of European commercial pigs examined by an in-depth haplotype analysis on chromosome 1 Frontiers in Genetics. ,vol. 5, pp. 442- 442 ,(2015) , 10.3389/FGENE.2014.00442
Marianne O. Larsen, Michael Wilken, Carsten F. Gotfredsen, Richard D. Carr, Ove Svendsen, Bidda Rolin, Mild streptozotocin diabetes in the Göttingen minipig. A novel model of moderate insulin deficiency and diabetes. American Journal of Physiology-endocrinology and Metabolism. ,vol. 282, ,(2002) , 10.1152/AJPENDO.00564.2001
C. J. Phelps, Production of alpha 1,3-Galactosyltransferase-Deficient Pigs Science. ,vol. 299, pp. 411- 414 ,(2003) , 10.1126/SCIENCE.1078942
Jessica C. Sieren, David K. Meyerholz, Xiao-Jun Wang, Bryan T. Davis, John D. Newell, Emily Hammond, Judy A. Rohret, Frank A. Rohret, Jason T. Struzynski, J. Adam Goeken, Paul W. Naumann, Mariah R. Leidinger, Agshin Taghiyev, Richard Van Rheeden, Jussara Hagen, Benjamin W. Darbro, Dawn E. Quelle, Christopher S. Rogers, Development and translational imaging of a TP53 porcine tumorigenesis model Journal of Clinical Investigation. ,vol. 124, pp. 4052- 4066 ,(2014) , 10.1172/JCI75447
J. Hauschild, B. Petersen, Y. Santiago, A.-L. Queisser, J. W. Carnwath, A. Lucas-Hahn, L. Zhang, X. Meng, P. D. Gregory, R. Schwinzer, G. J. Cost, H. Niemann, Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 12013- 12017 ,(2011) , 10.1073/PNAS.1106422108