Stroke MRI in intracerebral hemorrhage: is there a perihemorrhagic penumbra?

摘要: Background and Purpose— Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracerebral hemorrhage (ICH). The search for surrogate parameters that allow treatment stratification spontaneous ICH continues. We sought assess the presence prognostic effect of perihemorrhagic ischemic changes hypoperfusion in prospective stroke MRI study. Methods— performed 32 patients with hyperacute (mean, 16.9±17.2 mL) within 6 hours symptom onset 3.1±1.3 hours). Clinical data at baseline (National Institutes Health Stroke Scale) on day 90 (Barthel Index, modified Rankin were assessed. Perihemorrhagic perfusion- diffusion-weighted imaging assessed 1-cm-wide area around clot. Results— Despite mild mean transit time prolongation 0.7±1.1 second, there no significant apparent diffusion coefficient or indicating irreversible...