Advances in osteogenesis imperfecta.
作者： William G. Cole
DOI: 10.1097/00003086-200208000-00003
关键词: Genetic enhancement 、 Bioinformatics 、 Medicine 、 Somatic cell 、 Disease 、 Mesenchymal stem cell 、 Osteogenesis imperfecta 、 Stromal cell 、 Transplantation 、 Type I collagen
摘要: Considerable progress has been made in many aspects of osteogenesis imperfecta. The international Sillence classification imperfecta is being expanded to include a greater range subgroups patients. Attempts are identify the genes causing forms and related syndromes that not caused by mutations Type I collagen genes. In medium-term studies, bisphosphonate treatment shown be first method improve clinical course disease significantly. Somatic cell therapy, using allogeneic bone marrow mesenchymal stromal transplantation, their early phases development for use humans with gene which aims inactivate mutation, evaluated laboratory animal studies.
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