Apolipoprotein E Status as a Predictor of the Development of Alzheimer's Disease in Memory-Impaired Individuals

摘要: Objective. —The outcome of patients with mild cognitive impairment is not known, yet these present a difficult dilemma for the clinician. This study was designed to characterize group and determine whether presence e4 allele on apolipoprotein E gene (APOE) predictor that outcome. Design. —A prospective, longitudinal inception cohort. Setting. —General community clinic. Participants. consecutive sample 66 who met criteria diagnosis had at least one clinical reevaluation identified from Mayo Clinic Alzheimer's Disease Center/Alzheimer's Patient Registry. Interventions. —We evaluated initially 12- 18-month intervals up 54 months using standard neurological neuropsychological measures such as Mini-Mental State Examination, Dementia Rating Scale, Wechsler Adult Intelligence Scale—Revised, Memory Free Cued Selective Reminding Test. TheAPOEstatus determined. Main Outcome Measure. development dementia determined by theDiagnostic Statistical Manual Mental Disorders, Revised Third Editionand National Institute Neurological Communicative Disorders Stroke/ Related Association criteria. Results. —Sixty-six individuals been reevaluated once (mean 18 months), 36 twice 22 three occasions conversion rates 24%, 44%, 55%, respectively. A multivariate Cox regression model demonstrated possession anAPOEe4 strongest Conclusions. —These data suggest following: (1) can be clinically defined, (2) many members this progress disease, (3)APOEe4 status appears strong progression. (JAMA. 1995;273:1274-1278)