Simultaneous determination of pyrethroid and pyrethrin metabolites in human urine by gas chromatography–high resolution mass spectrometry
作者： G LENG , W GRIES
DOI: 10.1016/J.JCHROMB.2004.10.044
关键词: Phenothrin 、 Pyrethroid 、 Tetramethrin 、 Cyfluthrin 、 Carboxylic acid 、 Resolution (mass spectrometry) 、 Chromatography 、 Chemistry 、 Pyrethrin 、 Resmethrin
摘要: A new developed gas chromatographic–high resolution mass spectrometric method for the sensitive simultaneous determination of trans-chrysanthemumdicarboxylic acid, cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane 3-phenoxybenzoic acid 4-fluoro-3-phenoxybenzoic in human urine is presented. These metabolites are biomarkers an exposure to pyrethrum, allethrin, resmethrin, phenothrin, tetramethrin, cyfluthrin, cypermethrin, deltamethrin or permethrin. Therefore, with help this first time a complete assessment pyrethroid pyrethrin insecticides possible. After hydrolysis extraction tert-butyl-methyl-ether residue derivatized 1,1,1,3,3,3-hexafluoroisopropanol analyzed by GC/HRMS electron impact mode (detection limits < 0.1 μg/l) as well negative chemical ionization limit < 0.05 μg/l urine).
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