ABC transporters at the blood-brain barrier.
作者： Anne Mahringer , Gert Fricker
DOI: 10.1517/17425255.2016.1168804
关键词: Transport protein 、 Cell biology 、 Blood–brain barrier 、 Endothelial stem cell 、 Abcg2 、 Biochemistry 、 Biology 、 ATP-binding cassette transporter 、 P-glycoprotein 、 Alzheimer's disease 、 Signal transduction
摘要: ABSTRACTIntroduction: The blood–brain barrier (BBB) possesses an outstanding ability to protect the brain against xenobiotics and potentially poisonous metabolites. Owing this, ATP binding cassette (ABC) export proteins have garnered significant interest in research community. These transport are predominantly localized luminal membrane of microvessels, where they recognize a wide range different substrates them back into blood circulation.Areas covered: This review summarizes recent findings on these proteins, including their expression endothelial cell substrate recognition. Signaling cascades underlying function will be discussed as well role diseases such Alzheimer’s disease, epilepsy, amyotrophic lateral sclerosis tumors.Expert opinion: ABC transporters represent integral part human transportome particular at ...
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