Studies on the Chemical Composition and Biologieal Properties of Transfer Factor
作者： Kai Krohn , Arja Uotila , Juhani Väisänen , Pentti Gröhn
DOI: 10.1016/S0340-904X(77)80056-0
关键词: Chemistry 、 Sephadex 、 Biochemistry 、 Uracil 、 Tyrosine 、 Fraction (chemistry) 、 Chromatography 、 Biological activity 、 Chemical composition 、 Molecule 、 Hypoxanthine 、 General Medicine
摘要: Dialyzable transfer factor (dTF) was fractionated on Sephadex G-10 and G-25 fine columns, biological activity found in 3 fractions. One of these, designated VIa, having a tendency to adsorb the gel, shown have therapeutic effect certain immunological diseases. Analysis this fraction thin-layer gas chromatography with infrared mass spectroscopy indicated that about half composed uracil; additional unidentified heterocyclic aromatic substances were present fraction. Adjacent V contained tyrosine small polyribonucleotide, VII hypoxanthine components. Our results suggest dTF is not mediated through an immunologically specific informational molecule, but rather based non-specific stimulation expression immune response.
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