Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor.

摘要: A boy aged 6 years with severe chronic mucocutaneous candidiasis of the granulomatous variety has been treated dialysable transfer factor. Before treatment he was unable to express delayed hypersensitivity. His lymphocytes were able, however, produce migration inhibitory factor following in vitro challenge soluble candida antigens, but this activation not accompanied by a significant increase DNA synthesis. The resulted temporary clinical improvement and return normal his immune responses. After relapse was, months later, once more injected factor, which again proved effective. Evidence is presented suggests defect monocyte-macrophage function patient pathogenesis granulomata discussed. It postulated that an amplifying mechanism involving lymphocyte-macrophage interaction required for expression hypersensitivity reactions effective elimination Candida albicans.