Ruminations on dietary restriction and aging.

摘要: Calorie restriction has been known for many decades to extend the life span of rodents. Since more recent discovery that a long-term reduction in nutrient intake also extends nearly every invertebrate model organism used aging research, mechanisms behind longevity benefits this intervention have under intense scrutiny. While models developed yeast, worms, and flies, molecular governing extension by calorie remain controversial, resulting great anticipation mammalian studies testing these models. Here we discuss links between enhanced with emphasis on evolutionarily conserved response signaling.