The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies.
作者： Donald K. Ingram , George S. Roth , Mark A. Lane , Mary Ann Ottinger , Sige Zou
DOI: 10.1007/S10522-006-9013-2
关键词: Longevity 、 Medicine 、 Geriatrics gerontology 、 Low calorie diet 、 Restricted diet 、 Nutritional status 、 Disease risk 、 Clinical trial 、 Gerontology
摘要: Based on results emerging from long-term studies of dietary restriction in rhesus monkeys, we offer our views regarding whether can increase longevity humans. Because lifespan data monkeys remain inconclusive currently, respond that “we do not for sure.” the vast literature effects healthy, low calorie diets health and a wide range species, including humans, based monkey suggesting improves markers disease risk health, think so.” it is unlikely an experimental study will ever be designed to address this question never know sure. ” We suggest debate clearly academic exercise; thus, would more compelling discussion should focus basic mechanisms DR discovered if such discoveries lead development effective mimetics. Even proof or mimetics humans likely emerge, endpoints incidence as well maintenance function examined human clinical trials, these highly relevant evaluating effectiveness treatments.
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