TREATMENT OF DIALYSIS OSTEOMALACIA WITH DESFERRIOXAMINE
作者： DouglasJ. Brown , KathrynN. Ham , JohnK. Dawborn , JosephM. Xipell
DOI: 10.1016/S0140-6736(82)90544-X
关键词: Dialysis 、 Urology 、 Osteomalacia 、 Osteoid 、 Effective treatment 、 Bone biopsy 、 Surgery 、 Normal bone 、 Medicine
摘要: Two patients with severe dialysis osteomalacia, whose fractures and deformities had become progressively worse over 3 years, were treated desferrioxamine (DFO). They improved rapidly 6 months able to stop taking analgesics return normal activities. Pre-treatment bone biopsy samples contained extensive osteoid covering trabecular surfaces. Electron microscopy showed morphological abnormalities in the matrix. Treatment brought about a decrease extent depth of osteoid, but matrix remained. Energy-dispersive X-ray microanalysis presence several metals not seen bone. The changes trace after DFO treatment consistent. Atomic absorption analysis no significant change aluminium content treatment. appears be an effective for osteomalacia.
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