MiR-34b regulates cervical cancer cell proliferation and apoptosis.
作者： Zhen Cao , Gong Zhang , Conghua Xie , Yunfeng Zhou
DOI: 10.1080/21691401.2019.1614013
关键词: Flow cytometry 、 Cancer research 、 Cervical cancer 、 Blot 、 Cell growth 、 Transfection 、 Apoptosis 、 Biology 、 Cell culture 、 Stromal Invasion
摘要: Objectives: MiR-34b is a tumour suppressor in different kinds of carcinomas. This study investigated the role miR-34b proliferation and apoptosis cervical cancer. Materials methods: The expression 60 cancer patients were quantified by RT-PCR correlated with their clinicopathological parameters. Besides, there significant reverse relationship between miR-43b TGF-β1 tissues. Cell was detected CCK-8 assays flow cytometry cell lines transfected mimics. Western blotting, quantitative transcription-PCR (RT-PCR) luciferase conducted to analyze regulation lines. Results: Here, we found be downregulated comparison adjacent normal Expression levels associated enhanced malignant potential, such as stage stromal invasion. overexpression potently suppressed induced Conclusions: contribute are potential targets for therapeutics.
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