Cancer and SOX proteins: New insight into their role in ovarian cancer progression/inhibition.
作者： Milad Ashrafizadeh , Shahram Taeb , Kiavash Hushmandi , Sima Orouei , Md. Shahinozzaman
DOI: 10.1016/J.PHRS.2020.105159
关键词: Transcription factor 、 Testis determining factor 、 Ovarian cancer 、 PI3K/AKT/mTOR pathway 、 MAPK/ERK pathway 、 Cancer research 、 SOX Transcription Factors 、 Cancer 、 microRNA 、 Biology
摘要: Transcription factors are potential targets in disease therapy, particularly cancer. This is due to the fact that transcription regulate a variety of cellular events, and their modulation has opened new window cancer therapy. Sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) proteins involved developmental processes such as embryogenesis. It been reported abnormal expression SOX associated with development different cancers, ovarian (OC). In present review, our aim provide mechanistic review involvement members OC. may suppress and/or promote aggressiveness proliferation OC cells. Clinical studies have also confirmed diagnostic prognostic Notably, demonstrated relationship between other molecular pathways ST6Ga1-I, PI3K, ERK so on, leading more complexity. Furthermore, can be affected by upstream mediators microRNAs, long non-coding RNAs, on. worth mentioning each member corelated stages determines response cells chemotherapy. These topics discussed this shed some light on role
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