S -2-hydroxyglutarate regulates CD8 + T-lymphocyte fate
作者： Petros A. Tyrakis , Asis Palazon , David Macias , Kian. L. Lee , Anthony. T. Phan
DOI: 10.1038/NATURE20165
关键词: Isocitrate dehydrogenase 、 Biology 、 Antigen 、 Cancer cell 、 Cellular differentiation 、 CD8 、 Biochemistry 、 DNA demethylation 、 Immune system 、 Cytotoxic T cell 、 Cell biology
摘要: … Here we demonstrate that CD8 + T lymphocytes produce 2-hydroxyglutarate (2HG) in response to … S-2HG constitutes the majority of the 2HG pool, and we show that S-2HG alters the …
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