Translational Medicine: Functional Biomarkers for Drug Development of “Cognitive Enhancers” in Schizophrenia
作者： Georg Winterer
DOI: 10.1007/978-1-4020-9464-4_4
关键词: Psychiatry 、 Psychology 、 Schizophrenia (object-oriented programming) 、 Valid Biomarker 、 Drug development 、 Electroencephalography 、 Neuroscience 、 Translational medicine 、 Cognition
摘要: Biomarkers are the bridge between basic and clinical research enable us to speed up pro cess of drug development. In process devel opment “cognitive enhancers” for treatment schizophrenia, usefulness biomarkers is increas ingly realized. this chapter, we will introduce concept discuss its application with regard drugs that developed purpose cognitive enhancement in schizophrenia. While focus sing on functional biomarkers, i.e., mag netic resonance imaging (fMRI) electrophysiology (EEG), it be clearly delineated what currently feasible, kind limitations still exist needs done future optimise available biomarkers. addition, those listed which thought qualify as defi cits schizophrenia or at least close one may call a valid biomarker
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