Management of adult soft tissue sarcomas of the head and neck

作者: Remco de Bree , Isaäc van der Waal , Eelco de Bree , C. René Leemans

DOI: 10.1016/J.ORALONCOLOGY.2010.09.001

关键词: PathologySoft tissue sarcomaSoft tissueSarcomaFibrosarcomaSinonasal TractAngiosarcomaScalpMedicineAdult Soft Tissue Sarcoma

摘要: Adult soft tissue sarcoma of the head and neck are rare represent a heterogeneous group tumours different histological variants. Management these neoplasms presents great challenge. Malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma malignant peripheral nerve sheath tumour most frequently found types in neck. Although traditional morphological assessment is foundation clinical decision making, role immunohistochemistry molecular biology useful for diagnosis, prognosis identification possible targets therapy. The involved sites scalp/face, sinonasal tract/anterior skull base parotid/neck. management sarcomas primarily surgical. Since it difficult to obtain wide margins during surgical treatment sarcomas, because anatomic constraints, patients undergo post-operative irradiation. Survival varies from 50 80%. Prognostic factors grade, margin status size. With further insight into sarcoma, modern imaging techniques new options, we will certainly be able improve outcome with upcoming years.

参考文章(62)
Christopher D.M. Fletcher, Krisjnan Unni, Fredrik Mertens, World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone IARC Press. ,(2002)
Th. Otte, O. Kleinsasser, Liposarcoma of the head and neck. European Archives of Oto-rhino-laryngology. ,vol. 232, pp. 285- 291 ,(1981) , 10.1007/BF00457454
Christopher DM Fletcher, K Krishnan Unni, Fredrik Mertens, None, Pathology and genetics of tumours of soft tissue and bone IARC Press. ,(2002)
C.B. Lajer, S. Daugaard, H.S. Hansen, J. Kirkegaard, S. Holmgaard, M.E. Christensen, Soft tissue sarcomas of the head and neck: a single-centre experience Clinical Otolaryngology. ,vol. 30, pp. 176- 182 ,(2005) , 10.1111/J.1365-2273.2004.00951.X
John A. Greager, Minu K. Patel, Henry A. Briele, Michael J. Walker, Tapas K. Das Gupta, Soft tissue sarcomas of the adult head and neck. Cancer. ,vol. 56, pp. 820- 824 ,(1985) , 10.1002/1097-0142(19850815)56:4<820::AID-CNCR2820560420>3.0.CO;2-P
J.P. Van Damme, S. Schmitz, J.P. Machiels, C. Galant, V. Grégoire, B. Lengelé, M. Hamoir, Prognostic factors and assessment of staging systems for head and neck soft tissue sarcomas in adults Ejso. ,vol. 36, pp. 684- 690 ,(2010) , 10.1016/J.EJSO.2010.05.020
Jerry L. Barker, Arnold C. Paulino, Susan Feeney, Timothy McCulloch, Harry Hoffman, Locoregional treatment for adult soft tissue sarcomas of the head and neck: an institutional review. Cancer Journal. ,vol. 9, pp. 49- 57 ,(2003) , 10.1097/00130404-200301000-00009
Merdan Fayda, Gorkem Aksu, Fulya Yaman Agaoglu, Ahmet Karadeniz, Emin Darendeliler, Musa Altun, Gunter Hafiz, The role of surgery and radiotherapy in treatment of soft tissue sarcomas of the head and neck region: Review of 30 cases Journal of Cranio-Maxillofacial Surgery. ,vol. 37, pp. 42- 48 ,(2009) , 10.1016/J.JCMS.2008.07.007
Brandon G. Bentz, Bhuvanesh Singh, James Woodruff, Murray Brennan, Jatin P. Shah, Dennis Kraus, Head and neck soft tissue sarcomas: a multivariate analysis of outcomes. Annals of Surgical Oncology. ,vol. 11, pp. 619- 628 ,(2004) , 10.1245/ASO.2004.03.006
Sanjay B. Dudhat, Rajesh C. Mistry, Thomas Varughese, Abdul R. Fakih, Roshan F. Chinoy, Prognostic factors in head and neck soft tissue sarcomas Cancer. ,vol. 89, pp. 868- 872 ,(2000) , 10.1002/1097-0142(20000815)89:4<868::AID-CNCR20>3.0.CO;2-9