Calcium-sensitive ROS-GC1 signaling outside of photoreceptors: A common theme
作者： Venkateswar Venkataraman , Robert G. Nagele
DOI: 10.1007/978-1-4615-0927-1_9
关键词: Pineal gland 、 Internal medicine 、 Endocrinology 、 Hyperpolarization (biology) 、 Depolarization 、 Pinealocyte 、 Retina 、 Neuroscience 、 Olfactory bulb 、 Neuron 、 Biology 、 Signal transduction
摘要: Until now, ROS-GC1 signal transduction system was thought to be exclusive photoreceptors in the retina. Two recent reports, however, now show that this is not case. In one, has been identified and characterized pinealocyte neurons. This signaling modulated by norepinephrine. However, response of individual neuron norepinephrine depends on whether GCAP1-linked (results hyperpolarization) or S100β-linked depolarization) pathway operational pinealocyte. The results hyperpolarization, while pathway, depolarization. two pathways are mutually exclusive. other report, calcium-modulated ROS-GC1:GCAP1 discovered mitral cells olfactory bulb. These findings raise possibility a common theme ROS-GC may utilized wide variety neurosensory cells. idea also supported from evolutionary functional perspectives.
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