Telephone-administered psychotherapy in combination with antidepressant medication for the acute treatment of major depressive disorder

摘要: Abstract Background Telephone-administered psychotherapies (T-P) provided as an adjunct to antidepressant medication may improve response rates in major depressive disorder (MDD). The goal of this study was compare telephone-administered social rhythm therapy (T-SRT) and intensive clinical management (T-ICM) adjuncts for MDD. A secondary T-P with Treatment Usual (TAU) adjunctive treatment Methods 221 adult out-patients MDD, currently depressed, were randomly assigned 8 sessions weekly T-SRT ( n =110) or T-ICM =111), administered agomelatine. Both entirely by telephone, trained psychologists who blind other aspects treatment. patients a posteriori matched depressed outpatients receiving TAU (controls). primary outcome measure the percentage responders at weeks post-treatment. Results No significant differences found between T-ICM. But associated higher (65.4% vs 54.8%, p =0.02) trend toward remission (33.2% 25.1%; =0.06) compared TAU. Limitations Short term study. Conclusions This is first assessing short-term effects add-on, brief, psychotherapy treated medication. Eight telephone-delivered resulted improved relative alone.