A study of adenosine 3′:5′-cyclic monophosphate, sodium butyrate and cortisol as inducers of HeLa alkaline phosphatase
作者： M.J. Griffin , G.H. Price , K.L. Bazzell , R.P. Cox , N.K. Ghosh
DOI: 10.1016/0003-9861(74)90073-3
关键词: Butyric acid 、 Phosphatase 、 Adenosine 、 HeLa 、 Biochemistry 、 Molecular biology 、 Sodium butyrate 、 Chemistry 、 Enzyme 、 Alkaline phosphatase 、 Cyclic nucleotide
摘要: Abstract The role of adenosine 3′:5′-cyclic monophosphate in the cortisol-mediated induction HeLa 65 alkaline phosphatase was investigated. Although growth these cells with 0.5–1.0 m N 6 , O 2 ′-dibutyryl induces a 5- to 8-fold increase cellular activity after 72 hr, neither cAMP nor theophylline induce at concentrations up 1 . Sodium butyrate enzyme as well dibutyryl cAMP. Moreover, kinetics show sodium be more efficient inducer than cAMP, inducing quickly cortisol. This suggests that butyric acid cleaved from by is mediator when cyclic nucleotide derivative used.
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