Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited
作者： Karl H. Plate , Alexander Scholz , Daniel J. Dumont
DOI: 10.1007/S00401-012-1066-5
关键词: Vascular endothelial growth factor 、 Pathology 、 Angiogenesis 、 Cancer research 、 Vasculogenesis 、 HIF1A 、 Cancer 、 Biology 、 Sprouting angiogenesis 、 Targeted therapy 、 Bevacizumab
摘要: The cellular and molecular mechanisms of tumor angiogenesis its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts both biology targeted therapy. Currently, (1) sprouting angiogenesis, (2) vascular co-option, (3) intussusception, (4) vasculogenic mimicry, (5) bone marrow-derived vasculogenesis, (6) stem-like cell-derived vasculogenesis (7) myeloid cell-driven considered to contribute angiogenesis. Many these processes have been described developmental angiogenesis; however, the relative contribution relevance human brain remain unclear. Preclinical models support a role co-option glioma vascularization, whereas other four remains controversial rather enigmatic. anti-angiogenesis drug Avastin (Bevacizumab), which targets VEGF, has become one most popular drugs world. Anti-angiogenic may lead normalization as such facilitate conventional cytotoxic chemotherapy. However, preclinical clinical studies suggest that anti-VEGF using bevacizumab also pro-migratory phenotype resistant glioblastomas thus actively promote invasion recurrent growth. This review focusses on malignant particular bone-marrow-derived vasculogenesis.
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Daniel J. Dumont, Janet Rossant, Ron A Conlon, Terry P. Yamaguchi, Martin L. Breitman, tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors Oncogene. ,vol. 7, pp. 1471- 1480 ,(1992)
Haymo Kurz, Johannes Korn, Bodo Christ, Morphogenesis of Embryonic CNS Vessels Cancer treatment and research. ,vol. 117, pp. 33- 50 ,(2004) , 10.1007/978-1-4419-8871-3_2
Rakesh K. Jain, Lance L. Munn, Leaky vessels? Call Ang1! Nature Medicine. ,vol. 6, pp. 131- 132 ,(2000) , 10.1038/72212
J Jääskeläinen, M Haltia, K Alitalo, E Hatva, A Paetau, A Kaipainen, P Mentula, Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. American Journal of Pathology. ,vol. 146, pp. 368- 378 ,(1995)
Manabu Onishi, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Kentaro Fujii, Koichi Yoshida, Satoshi Inoue, Hiroyuki Michiue, E. Antonio Chiocca, Balveen Kaur, Isao Date, Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models Neuropathology. ,vol. 33, pp. 162- 174 ,(2013) , 10.1111/J.1440-1789.2012.01344.X
G. Breier, B. Millauer, A. Ullrich, W. Risau, K. H. Plate, Up-Regulation of Vascular Endothelial Growth Factor and Its Cognate Receptors in a Rat Glioma Model of Tumor Angiogenesis Cancer Research. ,vol. 53, pp. 5822- 5827 ,(1993)
Nina Jones, Kristiina Iljin, Daniel J. Dumont, Kari Alitalo, Tie receptors: new modulators of angiogenic and lymphangiogenic responses Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 257- 267 ,(2001) , 10.1038/35067005
Douglas Hanahan, Signaling Vascular Morphogenesis and Maintenance Science. ,vol. 277, pp. 48- 50 ,(1997) , 10.1126/SCIENCE.277.5322.48
Ashwatha Narayana, Deborah Gruber, Saroj Kunnakkat, John G. Golfinos, Erik Parker, Shahzad Raza, David Zagzag, Patricia Eagan, Michael L. Gruber, A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma. Journal of Neurosurgery. ,vol. 116, pp. 341- 345 ,(2012) , 10.3171/2011.9.JNS11656
Donald M McDonald, Alexander JE Foss, Endothelial cells of tumor vessels: abnormal but not absent. Cancer and Metastasis Reviews. ,vol. 19, pp. 109- 120 ,(2000) , 10.1023/A:1026529222845