STIMULATION BY FOOD OF PERIPHERAL PLASMA IMMUNOREACTIVE GROWTH HORMONE RELEASING FACTOR
作者： A. M. SOPWITH , ELIZABETH S. PENNY , G. M. BESSER , LESLEY H. REES
DOI: 10.1111/J.1365-2265.1985.TB03245.X
关键词: Internal medicine 、 Hypothalamus 、 Biology 、 Neuropeptide 、 Ingestion 、 Peptide hormone 、 Stimulation 、 Meal 、 Pituitary gland 、 Endocrinology 、 Postprandial
摘要: SUMMARY A highly specific radioimmunoassay has been used to study changes in peripheral human plasma growth hormone releasing factor (GRF) following the ingestion of food. From a mean basal concentration 11.8 pg/ml (range <7–15.4 pg/ml) six normal individuals overnight fast, circulating GRF-like immunoreactivity increased maximum 36.7 20.2–77.0 sampled 120 min after mixed breakfast. This increase GRF was accompanied by suppression rather than stimulation hormone. The predominant source may therefore extrahy-pothalamic and responds an oral food stimulus.
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