X-ray phase-contrast computed tomography visualizes the microstructure and degradation profile of implanted biodegradable scaffolds after spinal cord injury
作者： Kenta Takashima , Masato Hoshino , Kentaro Uesugi , Naoto Yagi , Shojiro Matsuda
DOI: 10.1107/S160057751402270X
关键词: X-ray 、 Scaffold 、 Computed tomography 、 Tissue engineering 、 Spinal cord 、 Spinal cord injury 、 Biodegradable scaffold 、 Biomedical engineering 、 Microstructure 、 Materials science
摘要: Tissue engineering strategies for spinal cord repair are a primary focus of translational medicine after injury (SCI). Many tissue employ three-dimensional scaffolds, which made biodegradable materials and have microstructure incorporated with viable cells bioactive molecules to promote new generation functional recovery SCI. It is therefore important develop an imaging system that visualizes both the scaffolds their degradation process Here, X-ray phase-contrast computed tomography based on Talbot grating interferometer described it shown how can visualize polyglycolic acid scaffold, including its microfibres, implantation into injured cord. Furthermore, images revealed occurred from end centre braided scaffold in 28 days The present report provides first demonstration technique SCI research. versatile be used broad range preclinical applications strategies.
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