Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury.

摘要: Abstract Bridges implanted into the injured spinal cord function to stabilize injury, while also supporting and directing axon growth. The architecture of bridge is critical its function, with pores support cell infiltration that integrates implant host channels direct elongation. Here, we developed a sucrose fiber template create poly(lactide-co-glycolide) multiple channel bridges for implantation lateral hemisection had 3-fold increase in number relative previous an overall porosity ranging from approximately 70%–90%. Following rat mouse models, axons were observed within all conditions. density increased nearly 7-fold fewer channels. Furthermore, increasing substantially axons, which correlated extent throughout bridge. Analysis these types identified presence mature oligodendrocytes at higher porosities. These results demonstrate influence re-growth through injury. provide platform technology capable being combined delivery regenerative factors ultimate goal achieving functional recovery.